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    ASBMR 2011 Annual Meeting

    Peri-Aortic Fat Is Negatively Associated with Volumetric Bone Mineral Density, Cross-Sectional Area and Compressive Strength of Lumbar Vertebrae: the Framingham Osteoporosis Study

    Categories:
     Osteoporosis - Epidemiology
     Aging and Muscle/Bone Interactions
     Osteoporosis - Pathophysiology

    Plenary Sessions, Presentation Number: FR0347
    Session: Welcome Reception & Plenary Poster Session
    Friday, September 16, 2011 5:45 PM - 7:00 PM, San Diego Convention Center, Hall GH

    Poster Sessions, Presentation Number: SA0347
    Session: Poster Session I & Poster Tours*
    Saturday, September 17, 2011 11:00 AM - 1:00 PM, San Diego Convention Center, Hall GH

    * Yi-Hsiang Hsu, HSL Institute for Aging Research, Harvard Medical School, USA, Caroline S. Fox, National Heart, Lung, and Blood's Framingham Heart Study, USA, Mary Bouxsein, Beth Israel Deaconess Medical Center, Harvard Medical School, USA, Udo Hoffmann, Massachusetts General Hospital, Department of Cardiac MR PET CT and Harvard University, USA, LA Cupples, Biostatstics Dept., School of Public Health, Boston University, USA, Douglas Kiel, Hebrew SeniorLife, USA

    Both obesity and osteoporosis are increasingly recognized as major health problems worldwide. The long prevailing view that BMI defined obesity is associated with beneficial effects on the skeleton has recently been challenged by contrasting studies demonstrating that visceral fat is associated with lower bone density. Peri-aortic adipose tissue volume (PAAT) is the adipose tissue surrounding the aorta, which is anatomically adjacent to the spine. Cellular studies have suggested that PAAT may have a paracrine effect on the adjacent aortic vessel walls leading to a higher risk of arterial disease. We hypothesized that PAAT is associated with bone measures and it may be due to its local paracrine effect on the adjacent lumbar vertebrae. Methods: To determine the association between PAAT and bone measures at the lumbar vertebrae, PAAT (cm3) and volumetric integral BMD (In.vBMD, cm3); volumetric trabecular BMD (Tb.vBMD, cm3); and cross-sectional area (CSA, cm2) of L3 were measured by QCT on 1,631 men and 1,507 women (mean age: 53±12.3 years old) from the Framingham Osteoporosis Study. The Compress Strength (CS, Newtons) of vertebrae body was calculated as ((In.vBMD x 3230) - 34.7) x CSA x 0.68. Subcutaneous abdominal tissue volume (SAT) and visceral abdominal tissue volume (VAT) were also estimated from the same QCT scans. Pearson partial correlation coefficients between PAAT and the QCT bone measures were estimated. Sex-specific mixed effects models were used to calculate least-squares means and to assess regression coefficients for the bone measures across PAAT quartiles. Results: PAAT was positively correlated with VAT, BMI and SAT with partial correlation coefficients (adjusted for age, sex and height) equal to 0.75, 0.52 and 0.41, respectively. Significantly negative correlations (-0.21 ~ -0.08) between PAAT and the bone measures were found in both men and women after adjusting for age, height, BMI and menopause status (women only). The magnitude of the correlations was stronger than that between BMI and the bone measures, and was in the opposite direction (Table). Adjusted for age, height and BMI, the multivariable-adjusted mean In.vBMD, Tb.vBMD, CSA and CS all significantly decreased from the lowest (Q1) to the highest (Q4) PAAT quartile (Figure: representative CS result) in both men and women. In conclusion, our study suggests that increased fat deposits adjacent to vertebrae may have a detrimental effect on bone density and strength of vertebrae.

    Disclosures: None

    * Presenting Authors(s): Yi-Hsiang Hsu, HSL Institute for Aging Research, Harvard Medical School, USA

    Attachments

    Table and Figure