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Amgen and UCB Announce FDA Advisory Committee Meeting To Review EVENITY™ (romosozumab) For The Treatment Of Osteoporosis In Postmenopausal Women At High Risk For Fracture

Amgen (NASDAQ:AMGN) and UCB (Euronext Brussels: UCB) announced that the U.S. Food and Drug Administration (FDA) Bone, Reproductive and Urologic Drugs Advisory Committee (BRUDAC) will review data supporting the Biologics License Application (BLA) for EVENITY™ (romosozumab) for the treatment of osteoporosis in postmenopausal women at high risk for fracture at a meeting on January 16, 2019. "After a fracture, postmenopausal women with osteoporosis are five times more likely to fracture in the subsequent year, and these fractures can be life-changing. Yet these patients often remain undiagnosed and untreated and could benefit from a potential new bone forming therapy that has been shown to reduce their risk of fracture within the first year," said David M. Reese, M.D., executive vice president of Research and Development at Amgen. "We look forward to discussing the efficacy and safety data from our EVENITY™ clinical program with the members of the Committee." Click here to read the full press release.


Renew your ASBMR Membership Before December 31!

December 31, 2018 is the day that your ASBMR membership expires! Renewing your membership provides you with the greatest access to our field’s global community: connections, education, collaborations, and scientific excellence. Helping you to continue to advance the science of bone, mineral, and musculoskeletal research is the foundation of all that we do at ASBMR. Renewing your membership is simple – log in to your member profile on www.asbmr.org and review your invoice today. Contact ASBMR Offices at 202-367-1161 or asbmr@asbmr.org if you have any questions!


Apply for the USBJI Young Investigator Initiative Grant Mentoring and Career Development Program!

The USBJI Young Investigator Initiative is a grant mentoring program providing early-career investigators an opportunity to work with experienced researchers in our field to assist them in securing funding and other survival skills required for pursuing an academic career. Participants rate highly the one-on-one mentoring with experienced researchers, the opportunity for inter-disciplinary and peer-to-peer exchange, and collaborations established during workshops. The unique aspect of this program is the opportunity for attendees to maintain a relationship with a mentor until their application is funded. The Spring 2019 workshop will take place on April 26-28, 2019, in Rosemont, Illinois, USA (Chicago). Click here to learn more about the program, eligibility requirements, and application instructions.  The deadline for applications is January 15, 2019.


Apply Now for the ASBMR Travel Grant to the NMRI Annual Workshop!

The ASBMR is pleased to offer one travel grant in the amount of $1,500 to an early career investigator conducting bone, mineral, or musculoskeletal related research interested in attending the Network of Minority Health Research Investigators (NMRI) Annual Workshop, held April 24-26, 2019. The purpose of the workshop is to encourage communication between current and potential biomedical research investigators and technical personnel interested in minority health research, including individuals from traditionally under-served communities: African American, Hispanic American, American Indian, Alaskan Native, Native Hawaiian, and other Pacific Islanders. Click here for complete eligibility requirements and to submit your application! Application deadline is February 18, 2019.


Have you Accessed the Highlights of ASBMR 2018 Online Yet?

The ASBMR 2018 Annual Meeting may be over, but you can still access vital research presented in Montréal with the ASBMR 2018 Annual Meeting Highlights presentation!
Watch and listen to this highly attended presentation by Roland Baron, D.D.S., Ph.D. and John P. Bilezikian, M.D. that synthesizes the most exciting basic, translational and clinical science presented at the meeting. The presentation – available free to ASBMR members, and for $50 USD to non-members – is navigable by topic and abstracts and includes video, a downloadable slide deck and links to 2018 abstracts. To view more presentations from the Annual Meeting and to view all of the meeting abstracts, please visit the ASBMR Education Resource Center.

JBMR® Highlights
Mineral homeostasis in murine fetuses is sensitive to maternal calcitriol, but not to absence of fetal calcitriol
Brittany A. Ryan, Kamal Alhani, K. Berit Sellars, Beth J. Kirby, René St‐Arnaud, Martin Kaufmann, Glenville Jones, Christopher S. Kovacs
First Published: 03 December 2018
Cannabinoid receptor 2 agonist prevents local and systemic inflammatory bone destruction in rheumatoid arthritis
Mo Zhu, Binqin Yu, Jiaxiang Bai, Ximing Wang, Xiaobin Guo, Yu Liu, Jiayi Lin, Su Hu, Wen Zhang, Yunxia Tao, Chunhong Hu, Huilin Yang, Yaozeng Xu, Dechun Geng
First Published: 03 December 2018
Regulator of G protein signaling protein 12 (Rgs12) controls mouse osteoblast differentiation via calcium channel/oscillation and Gαi‐ERK signaling
Ziqing Li, Tongjun Liu, Alyssa Gilmore, Néstor Más Gómez, Chuanyun Fu, Jormay Lim, Shuting Yang, Claire H Mitchell, Yi‐ping Li, Merry J Oursler, Shuying Yang
First Published: 29 November 2018
Prevention of Injury‐Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR
Mian Zhang, Hongxu Yang, Xianghong Wan, Lei Lu, Jing Zhang, Hongyun Zhang, Tao Ye, Qian Liu, Mianjiao Xie, Shibin Yu, Shaoxiong Guo, Wenhan Chang, Meiqing Wang
First Published: 29 November 2018
JBMR® Plus Highlights
Promoter Cre‐specific genotyping assays for authentication of Cre‐driver mouse lines
Greig Couasnay, Christopher Frey, Florent Elefteriou
First Published: 03 December 2018
Profilin 1 negatively regulates osteoclast migration in postnatal skeletal growth, remodeling and homeostasis in mice
Jumpei Shirakawa, Shuhei Kajikawa, Ralph T. Böttcher, Mercedes Costell, Yayoi Izu, Tadayoshi Hayata, Masaki Noda, Yoichi Ezura
First Published: 03 December 2018
Predictors of imminent risk of non‐vertebral fracture in older, high‐risk women: The Framingham Osteoporosis Study
Marian T. Hannan, Derek Weycker, Robert R. McLean, Shivani Sahni, Rebecca Bornheimer, Richard Barron, Thomas G. Travison, Douglas P. Kiel
First Published: 03 December 2018
Bone Science in the News
Bisphosphonates underused among older patients with myeloma
HemOnc Today (12/3/2018)
Program Aims to Reduce Hip Fractures
Mass General Hospital (12/1/2018)
Bone Indices on CT Scan Predicts Fracture Risk in Older Adults
Doctors Lounge (11/30/2018)
Denosumab versus zoledronic acid for preventing symptomatic skeletal events in Asian postmenopausal women with oestrogen-receptor-positive advanced breast cancer: an outcome analyses with a mean follow-up of 3 years
BMC Musculoskeletal Disorders (11/30/2018)
Osteoporosis risk rises sharply even for younger breast cancer survivors
Medical Xpress (11/29/2018)
Events Calendar
February 20 - 22, 2019
8th International Conference on Frailty & Sarcopenia Research (ICFSR2019)
Miami Beach, FL United States
March 11 - 12, 2019
U13 Bench-to-Bedside Conference: "Osteoporosis and Soft Tissue Disorders"
Bethesda, MD United States
Contact ASBMR
ASBMR Business Office
2025 M Street, NW
Suite 800
Washington, DC 20036-3309 USA
Tel.: +1 (202) 367-1161
Fax: +1 (202) 367-2161
Email: asbmr@asbmr.org

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