American Society for Bone and Mineral Research

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Clinical Use of Bone Densitometry

Guidelines based on systematic reviews and a cost-effectiveness analysis have suggested that it is worthwhile to measure BMD in white women older than 65 years and perhaps to use risk factors to select younger postmenopausal women for densitometry. Other potential clinical applications of BMD that have not yet been adequately studied include screening men or nonwhite women, monitoring BMD in patients receiving treatment, and using BMD to identify patients who should be evaluated for secondary causes of osteoporosis.

http://jama.ama-assn.org/content/288/15/1889.long

Bone-Density Testing Interval and Transition to Osteoporosis in Older Women

Although bone mineral density (BMD) testing to screen for osteoporosis (BMD T score, −2.50 or lower) is recommended for women 65 years of age or older, there are few data to guide decisions about the interval between BMD tests. Our data indicate that osteoporosis would develop in less than 10% of older, postmenopausal women during rescreening intervals of approximately 15 years for women with normal bone density or mild osteopenia, 5 years for women with moderate osteopenia, and 1 year for women with advanced osteopenia. (Funded by the National Institutes of Health.)

http://www.nejm.org/doi/full/10.1056/NEJMoa1107142

Cdh1 Regulates Osteoblast Function through an APC/C-Independent Modulation of Smurf1

In this manuscript the authors examine the role of Cdh1 an E3 ubiquitin ligase in osteoblast function. They find that it promotes E3 ligase activity of Smurf1 by a mechanism that is independent of the E3 ligase activity of Cdh1. These studies identify a cell-cycle-independent function of Cdh1 and establish it as an upstream regulator of Smurf1 activity.

http://www.cell.com/molecular-cell/retrieve/pii/S1097276511008549

Loss of Tankyrase-Mediated Destruction of 3BP2 Is the Underlying Pathogenic Mechanism of Cherubism.

Cherubism, autosomal-dominant syndrome, is caused by mutations in Sh3bp2, the gene that encodes the adaptor protein 3BP2. In this manuscript the authors show that Tankyrase, a member of the poly(ADP-ribose)polymerase (PARP) family, regulates 3BP2 stability through ADP-ribosylation and subsequent ubiquitylation by the E3-ubiquitin ligase RNF146 in osteoclasts. Cherubism mutations uncouple 3BP2 from Tankyrase-mediated protein destruction, which results in its stabilization and subsequent hyperactivation of the SRC, SYK, and VAV signaling pathways.

http://www.cell.com/retrieve/pii/S0092867411013493

Estrogen receptor-α expression in neuronal cells affects bone mass.

In this study the authors investigated the in vivo role of central estrogen receptor-α (ERα) expression on bone mass. Nestin-Cre mice were crossed with ERα(flox) mice to generate mice lacking ERα expression specifically in nervous tissue (nestin-ERα(-/-)). Bone mineral density was increased in both the trabecular and cortical bone compartments of nestin-ERα(-/-) mice compared with controls. The high bone mass phenotype in nestin-ERα(-/-) mice was mainly caused by increased bone formation. Serum leptin levels were elevated as a result of increased leptin expression in white adipose tissue (WAT) and slightly increased amount of WAT in nestin-ERα(-/-) mice. Leptin receptor mRNA levels were reduced in the hypothalamus but not in bone.

http://www.ncbi.nlm.nih.gov/pubmed/22215598

Not All Elderly People Benefit From Vitamin D Supplementation with Respect to Physical Function: Results From the Osteoporotic Fractures in Men Study, Hong Kong.

The authors studied 939 community-dwelling men aged 65 and older for cross-sectional analysis and 714 for longitudinal analysis with regards to the correlation between vitamin D status and a variety of measurements of physical function. After adjustment for potential confounding factors, serum 25OHD levels were not associated with baseline or 4-year change in physical performance measures.

http://onlinelibrary.wiley.com/doi/10.1111/j.1532-5415.2011.03789.x/abstract;jsessionid=16F4CE436F05120A182A646B75418960.d03t03?systemMessage=Wiley+Online+Library+will+be+disrupted+14+Jan+from+10-12+GMT+for+monthly+maintenance

1-6 of 6 results

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In The Field

Clinical Use of Bone Densitometry

Bone-Density Testing Interval and Transition to Osteoporosis in Older Women

Cdh1 Regulates Osteoblast Function through an APC/C-Independent Modulation of Smurf1

Loss of Tankyrase-Mediated Destruction of 3BP2 Is the Underlying Pathogenic Mechanism of Cherubism.

Estrogen receptor-α expression in neuronal cells affects bone mass.

Not All Elderly People Benefit From Vitamin D Supplementation with Respect to Physical Function: Results From the Osteoporotic Fractures in Men Study, Hong Kong.

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