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1-4 of 4 results

Engineering of a functional bone organ through endochondral ossification

These authors used a “developmental engineering” paradigm, to manipulate human mesenchymal stem cells to produce an ectopic “bone organ” with a size, structure, and functionality comparable to native bones.

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Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches.

This article demonstrates that the cells producing the critical cytokine Cxcl12, which supports hematopoietic stem cells and immune cell progenitors in mouse bone marrow “niches” varied and that there were distinct subgroups of Cxcl12 producing cells for different progenitor populations. Deletion of Cxcl12 from osteoblasts depleted certain early lymphoid progenitors but not HSCs or myeloerythroid progenitors, and did not mobilize these cells into circulation.

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CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance.

Similar to the article above, these authors selectively deleted Cxcl12 from different populations of niche stromal cell in mice and characterized the effect on various progenitor cell populations. Deletion of Cxcl12 from mineralizing osteoblasts has no effect on hematopoietic stem cells or lymphoid progenitors.

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Adolescent Girls With Anorexia Nervosa Have Impaired Cortical and Trabecular Microarchitecture and Lower Estimated Bone Strength at the Distal Radius.

The authors examined adolescent girls with anorexia nervosa (AN) by finite element analysis (FEA) to asses cortical microarchitecture and bone strength. They found that both cortical and trabecular microarchitecture are altered in adolescent girls with AN. FEA-estimated failure load was also decreased, indicating reduced bone strength.

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1-4 of 4 results

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Engineering of a functional bone organ through endochondral ossification

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches.

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance.

Adolescent Girls With Anorexia Nervosa Have Impaired Cortical and Trabecular Microarchitecture and Lower Estimated Bone Strength at the Distal Radius.

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