Article: Fracture rebound after Denosumab discontinuation
Extension of phase III FREEDOM trial shows an increase in vertebral fracture rate upon denosumab discontinuation to the level observed in untreated participants. Therefore, patients who discontinue denosumab should rapidly transition to an alternative antiresorptive treatment.
Article: Inflammatory markers in hip fractures
In a retrospective analysis of the large Cardiovascular Health Study cohort, increased serum IL-6 and white blood cell count were associated with increased hip fracture rate.
Article: Fiber intake and bone loss
A retrospective analysis of the Framingham cohort suggests that high dietary fiber intake reduces bone loss in men, though not in women. However, the effect is modest.
Article: Macrophages in heterotopic ossification
Depletion of mast cells and macrophages reduced injury-induced heterotopic ossification (HO) by half in a genetic mouse model of fibrodysplasia ossificans progressiva (FOP). Immune cells may represent a new target for reducing HO in FOP.
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