• Anorexia Nervosa & Bone Loss

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    Anorexia Nervosa & Bone Loss

    Course Overview

    Sponsored by the American Society for Bone and Mineral Research

    Learning Objectives

    1. Review the clinical impact of this disorder on bone mass
    2. Consider underlying mechanisms- including the effect of anorexigenic and orexigenic hormones
    3. Review results of therapeutic interventions to address low bone mass tested to date in this disorder

    Presenter Information

    Anne Klibanski, M.D.

    Anne Klibanski, M.D. is the Laurie Carrol Guthart Professor of Medicine at Harvard Medical School and Chief, Neuroendocrine Unit at Massachusetts General Hospital in Boston. She also directs the Clinical Research Center of the Harvard Catalyst CTSA. A major research focus involves the neuroendocrine regulation of body composition and bone metabolism. She is specifically interested in how human models of neuroendocrine dysregulation in under-nutrition and psychiatric disorders lead to low bone mass. She has explored the GHRH-GH-IGF-1 axis therapeutically in these states. Using a number of novel imaging techniques including fMRI of brain regions of interest involved in appetite regulation, and new multi-disciplinary approaches to the investigation of bone microarchitecture and fat depots, her current research in this area seeks to define the relationship between appetite regulatory hormones and bone metabolism.


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