This webinar will present information relevant for the understanding of the role of the Wnt signaling pathway in bone development and homeostasis. It will begin with a discussion about how the Wnt pathway was first discovered and the types of systems that were initially used to understand signaling mechanisms. This will be followed by a discussion about how alterations in the pathway were found to be associated with changes in human bone mass. Discussion related to work that helped define how the pathway works within the osteoblast lineage to regulate bone development and homeostasis will follow. Finally, an update of how the pathway is being targeted for treating various human diseases will be presented.
- Understand how the components of the Wnt signaling pathway were first discovered and defined.
- Describe how alterations in components of the pathway were initially linked to bone disease.
- Understand how genetically engineered mouse models have helped define mechanisms of action relevant to bone development and homeostasis
- Describe the current status of therapies designed to treat human disease by targeting this pathway
Supported by an education donation provided by Amgen
Length: 60 minutes