Annual Meeting

Friday, September 12, 2008

Plenary Symposium I: Children's Bone Health - Regulation of Bone Mass Accrual

9:30 a.m. – 12:00 p.m.

Co-Chairs:
Catherine Gordon, M.D., Children’s Hospital Boston
Thomas Carpenter, M.D., Yale University School of Medicine

Fetal and Neonatal Mineral Metabolism
Christopher Kovacs, M.D., FRCP, Memorial University of Newfoundland (Canada)

Regulation of Bone Strength in Children
Frank Rauch, M.D., Shriners Hospital for Children

Regulation of Bone Mass Accrual: Nutritional Effects
Jean-Philippe Bonjour, M.D., University Hospital of Geneva (Switzerland)

Winning the Battle Against Childhood Physical Inactivity: The Key to Bone Strength?
Heather McKay, Ph.D., University of British Columbia (Canada)

Growth Plate Biology: Lessons from Mouse Genetics
Henry Kronenberg, M.D., Massachusetts General Hospital

Symposium A (Basic): Tissue Engineering and Regenerative Medicine

2:00 p.m. – 3:30 p.m.

Co-Chairs:
Julie Glowacki, Ph.D., Brigham and Women’s Hospital
Rocky Tuan, Ph.D., National Institute of Arthritis and Musculoskeletal and Skin Diseases

Engineering Osteogenic Gel Niches to Enhance Bone Regeneration
Kristi Anseth, Ph.D., University of Colorado

Second Generation Issues in Cartilage Tissue Engineering
Daniel Grande, Ph.D., North Shore L.I.J. Health System

Mesenchymal Cells for Bone Engineering
John Davies, BDS, Ph.D., DSc, University of Toronto (Canada)

Symposium B (Clinical): Vitamin D - Clinical and Scientific Advances

2:00 p.m. – 3:30 p.m.

Co-Chairs:
David Goltzman, M.D., McGill University (Canada)
Sylvia Christakos, Ph.D., University of Medicine and Dentistry of New Jersey Medical School

Recent Advances in Biochemistry and Clinical Aspects of Vitamin D
Hector Deluca, Ph.D., University of Wisconsin, Madison

The Effects of Vitamin D on the Immune System
Margherita Cantorna, Ph.D., Pennsylvania State University

Clinical Development of Calcitriol as an Anticancer Agent: Current Status
Donald Trump, M.D., Roswell Park Cancer Institute

Symposium C (Clinical): Advances in Skeletal Dysplasia

3:45 p.m. – 5:15 p.m.

Co-Chairs:
Karen Lyons, Ph.D., University of California, Los Angeles
Francis Glorieux, M.D., Ph.D., McGill University (Canada)

Natriuretic peptide signaling and skeletal growth
Matthew Warman, M.D., Children's Hospital Boston and Harvard Medical School

Pseudohypoparathyroidism: Gs-alpha, Genetic Imprinting and the Regulation of Calcium and Phosphorous Homeostasis
Harald Jueppner, M.D., Massachusetts General Hospital

Molecular Signaling in Craniosynostosis
Ethylin Jabs, M.D., Mount Sinai School of Medicine

Symposium D (Basic): Novel Treatments of Bone Disease

3:45 p.m. – 5:15 p.m.

Co-Chairs:
Teresita Bellido, Ph.D., University Arkansas for Medical Sciences
Sundeep Khosla, M.D., Mayo Clinic

Mechanotransduction: What do Bone Cells Have to do with Treating Osteoporosis Anyway?
Clinton Rubin, Ph.D., State University of New York

Anabolic Mechanisms of PTH Action in Bone
Laurie Kay McCauley, D.D.S., Ph.D., University of Michigan

Wnt Signaling as a Therapeutic Target
Jennifer Westendorf, Ph.D., Mayo Clinic

Saturday, September 13, 2008

Plenary Symposium II: 30th Annual Meeting Anniversary Symposium: Bone and Mineral Research: Past, Present and Future

8:15 a.m. – 9:45 a.m.

Co-Chairs:
Paula Stern, Ph.D., Northwestern University Feinberg School of Medicine
Thomas John Martin, M.D., DSc, St. Vincent’s Institute, (Australia)

How Bones Came Alive: A Brief History of Bone and Mineral Research
Larry Raisz, M.D., University of Connecticut Health Center

Five Decades of PTH Research: Progress, Paradox and Potential
John Potts, M.D., Massachusetts General Hospital and Harvard Medical School

Bone Biology Beyond Its Own Garden
Patricia Ducy, Ph.D., Columbia University

Sunday, September 14, 2008

State-of-the-Art Lecture A: Technologies for the 21st Century

4:30 p.m. – 6:00 p.m.

Co-Chairs:
Steve Goldstein, Ph.D., University of Michigan
Jane Lian, Ph.D., University of Massachusetts Medical School

Nanomedicine: Novel Strategies for Theranostics in Diverse Disease Processes
Sam Wickline, M.D., Washington University in St. Louis

Genome Wide Association Studies for Skeletal Phenotypes
Douglas P. Kiel, M.D., MPH, Harvard Medical School

Factor and Histone Covalent Modifications in Genome Regulation
Shelley Berger, Ph.D., The Wistar Institute

State-of-the-Art Lecture B: Cancer and Bone

4:30 p.m. – 6:00 p.m.

Co-Chairs:
Toshio Matsumoto, M.D., Ph.D., University of Tokushima Graduate School of Medical Sciences (Japan)
Andrew Arnold, M.D., University of Connecticut Health Center

Complexities of tgfbeta Signaling in Bone Metastases
Theresa Guise, M.D., University of Virginia

Metastatic Niche and Role of Immune Cells
Greg Mundy, M.D., Vanderbilt University

The Problem of Breast Cancer Bone Metastases: Targeted Therapy for the Skeleton
Katherine Weilbacher, M.D., Washington University in St. Louis

Monday, September 15, 2008

Plenary Symposium III: Stem Cells

8:00 a.m. – 9:30 a.m.

Co-Chairs:
Jane Aubin, Ph.D., University of Toronto (Canada)
Paulo Bianco, M.D., University La Sapienza (Italy)

Regulation of Hematopoietic Stem Cell Migration, Retention and Development by Osteoclast/Osteoblast Interactions
Tsvee Lapidot, Ph.D., Weizmann Institute (Israel)

Hemapoetic Stem Cell Niche in Bone Marrow
Linheng Li, Ph.D., Stowers Institute for Medical Research

Molecular Switching of Osteoblastogenesis vs Adipogenesis
Shigeaki Kato, Ph.D., The University of Tokyo (Japan)

State-of-the-Art Lecture A: Role of Oxygen Sensing Pathways

4:30 p.m. – 6:00 p.m.

Co-Chairs:
Dwight Towler, M.D., Ph.D., Washington University in St. Louis
Ernestina Schipani, M.D., Ph.D., Massachusetts General Hospital

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
Gregg Semenza, M.D., Ph.D., The Johns Hopkins University School of Medicine

Role of HIF-1a in Angiogenic-Osteogenic Coupling
Thomas Clemens, Ph.D., University of Alabama at Birmingham

Genetic Studies of Oxygen Sensors : Relevance for Hypoxia Tolerance and Angiogenesis
Peter Carmeliet, M.D., Ph.D., University of Leuven (Belgium)

State-of-the-Art Lecture B: SERMs and SARMs

4:30 p.m. – 6:00 p.m.

Co-Chairs:
Barry Komm, Ph.D., Wyeth
Nancy Lane, M.D., University of California at Davis

Mechanisms and Therapeutic Application of Selective Androgen Receptor Modulators
Shalender Bhasin, M.D., Boston University School of Medicine

The Molecular Basis for SERM and SARM Action
Donald McDonell, Ph.D., Duke University Medical Center

Risks and Benefits of Raloxifene
Elizabeth Barrett-Connor, M.D., University of California at San Diego