ASBMR

Job Title	Job Description
Research Group Leader	Applicants should be early to mid career, independent researchers with a competitive publication track record in the area of bone research or related areas, particularly endocrinology, and outstanding scientific credentials. Successful candidates will demonstrate a research agenda that fits within the strategic research directions of the Bone Research Program, with an emphasis (but not limited to) osteoblast and osteoclast biology, bone cancer and metabolic bone disease (for more details on our research program see http://www.anzac.edu.au).
Manager/Associate Director, Laboratory Resources	Would you like to work for a premier provider of innovative solutions in drug discovery and development? MDS Pharma Services has an exciting opportunity as a Manager/Associate Director, Laboratory Resources at our Bothell, WA location. In this full-time position, you will be responsible for the management of our laboratory department and staff which includes technical and scientific oversight of the histology and bioassay lab in support of efficacy pharmacology studies. You will develop and administer budgets, performance requirements, and schedules. You will also monitor and control labor and capital expenditures and will interpret results of laboratory activities. You will provide operational oversight of the laboratory and technical guidance with regard to feasibility and timing to project teams. Other staff functions include interviewing, hiring, and training employees as well as addressing staff complaints. To apply, visit www.mdsps.com. EEO/AA
Assistant Professor/Associate Professor	Tenure-track faculty position in skeletal biology. The Division of Endocrinology at the University of Arkansas for Medical Sciences invites applications for a tenure-track faculty position within the Center for Osteoporosis and Metabolic Bone Diseases. More information about our center is available at http://endocrinology.uams.edu/research/center.asp. This is a full-time research position with appointment anticipated at the Assistant or Associate Professor level. The accepted candidate will be expected to develop an active research program and purse extramural funding. While applicants interested in all areas of skeletal biology will be considered, we are particularly interested in those that will complement existing programs focused on aging, oxidative stress, angiogenesis, hormone action, apoptosis, osteocytes, and the mechanisms of drug action.
MD 2-Year Post-Doctoral Fellowship	The Endocrine Unit at Massachusetts General Hospital and Harvard Medical School seeks MD or MD/PhD candidates with an interest in clinical research and osteoporosis for a funded 2-year postgraduate fellowship focusing on human studies in metabolic bone disease.
Scientist	Assist in the commercialization of bone building therapies and to develop secondary product pipelines. Examine molecule interactions with cell surface proteins. Perform manual high throughput cell culture based screening of small molecule libraries using standard operating protocol (SOP). Execute animal protocol development and animal preclinical studies, including the handling of animals. Perform histological analyses on bone tissues, including embedding in plastic using SOP. Preform microscopy and assist with computer histomorphometry. Maintain and upgrade the corporate web page. Keep detailed records of research and findings in laboratory notebook. Manage laboratory to ensure forward movement of product development. Assist in the preparation of scientific manuscripts for publication and in compiling data for filing patents and seminars. Participate in continuous education through reading relevant literature, attendance of internal and external scientific meetings and seminars.
Post-doctoral Fellow	Candidates must have a strong background in signaling, cell biology and molecular biology. Prior experience or a willingness to work with rodents is a must. Experience in light/confocal microscopy, bone histology and micro-CT is highly desirable but not essential as training in these areas will be provided.
Academic/Research - Rheumatology	RESEARCH AREA: MECHANISMS OF INFLAMMATORY ARTHRITIS AND BONE DESTRUCTION: A POSTDOCTORAL POSITION is available for research involving pathogenic mechanisms in inflammatory arthritis and bone destruction. Projects focus on; studies addressing the mechanisms of bone loss, erosion and repair in animal models of arthritis, analysis of contributing factors and cell types, and transcriptional regulation of genes involved in bone remodeling in inflammatory arthritis. Excellent collaborative research environment including multiple core facilities. The research will involve the use of well-validated animal models, histopathology, micro-CT, micro-array techniques, and quantitative PCR. Training in specific arthritis models and micro-CT will be provided.
Clinical Medical Scientist, Bone	The Clinical Medical Scientist, Bone will perform a range of activities – depending on departmental need and individual interests – to advance the clinical development of drug candidates and support the North American Medical Affairs strategy for the Bone Therapeutic Area. Specifically, the Scientistwill serve as the medical expert in Bone, identifying and executing projects that substantially contribute to late-stage product development. Throughout the continuum of product development, he or she will define, analyze and synthesize commercial input into clinical strategy, including study design, data analysis and interpretation, aligning with the overall direction and objectives of the program. Additionally, the Scientist will participate in the resolution of regulatory issues, working closely with colleagues in Regulatory Affairs and Marketing to ensure successful product registration. In support of market launch, he or she may also participate in denosumab North American Medical Affairs activities at local management meetings, governance boards and operating reviews functioning as a Company ambassador to opinion leaders, external bodies, institutions, societies and networks. For confidential consideration please submit a CV and contact information by e-mail to: lsibone@gmail.com Our client is an EEO/AA M/F/V/D employer, valuing and encouraging diversity in the workplace.
Post-doctoral fellow	This fellow will assist with studies of the integrative physiology of bone responses to dietary energy restriction (funded by Department of Defense) and to microgravity and radiation exposure (funded by National Space Biomedical Research Institute). Major duties will include organizing live animal protocols, over-seeing data analysis, assisting with manuscript preparation and presentation at national meetings, abd applying for extramural post-doctoral funding. Fellow will be encouraged to develop independent, parallel projects .
Postdoctoral Research Fellow/Research Scientist	Potential research topics include transcriptional regulation of chondrocyte differentiation/function and mechanisms of bone sialoprotein-mediated osteogenesis. Projects utilize various cell lines and primary cell culture systems, as well as transgenic/knockout mice. Tools of molecular cell biology and protein chemistry will be used routinely. The individual will be expected to independently plan experiments, interpret data, write manuscript, and present data at scientific meetings. The individual is also responsible for training less experienced research staff and performing other job related duties as assigned. To view complete position description and APPLY ONLINE ONLY go to http://jobs.kumc.edu and search for position J0020016. An EO/AA Employer.
Post doctoral position	Work on funded projects related to arthritis and tooth defects using in vitro analysis and animal models. Studies include DNA cloning, testing promoter deletions, EMSA, RT-PCR, real-time PCR, Western blot, oxygen radical work, analysis of transgenic and knock out mice.
Internists, Endocrinologists and Rheumatologists	INTERNISTS, ENDOCRINOLOGISTS, and RHEUMATOLOGISTS with expertise in the area of Osteoporosis to serve in the dynamic, highly challenging and innovative atmosphere of drug development and research. • Advance the public health through new drug development • Experience teaching and training opportunities • Interact with pharmaceutical companies • Work with a wide range of scientific disciplines in a team oriented atmosphere
Mouse Models for Genetic Bone Disease	Background The Bone and Extracellular Matrix Branch of NICHD conducts translational research on genetic disorders of bone. Our interest is in understanding the biochemical and molecular mechanisms by which defects in components of matrix cause bone disease, and then in applying this information for the care of our pediatric patients. Potential Projects We are seeking to fill a postdoctoral position employing murine models of genetic bone disease. The fellow will use the murine model previously generated in our lab, the Brtl knock-in mouse for osteogenesis imperfecta (OI), as well as lead generation of novel transgenic and knock-in mice. Potential projects involve both dominant and newly defined recessive OI: 1) Development of knock-in murine models for recessive OI, recently delineated in our lab (NEJM 355:2757; Nat Genet 39:359), and investigation of bone disease mechanism 2) Investigation of mechanism of bone quality improvement by homozygosity for a dominant collagen mutation; 3) Modeling novel approaches to OI therapy, (a) gene therapy of OI by hammerhead ribozymes specific for Brtl mutation (involves in vitro RNA studies and tissue culture, plus mouse studies), and (b) administration of chemical chaperones;
Post Doctoral Fellow	DUTIES: To help us understand the pathophysiology of induced pathologic calcifications that mimic those that arise in children with Juvenile Dermatomyositis by testing and analyzing a series of animal models in a state-of the-art research facility. To spearhead monthly journal club and renew current data, attend appropriate meetings, prepare manuscripts for publications and to learn the grant application process.
Postdoctoral Fellowship	Characterize mouse models in which cytokine genes have been conditionally deleted in bone cells. This will consist of quantifying changes in bone mass, gene expression, and histology.

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