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    Blocking antibody to the β-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis.

    The authors generated and characterized a polyclonal antibody to a 13-amino-acid-long peptide sequence within the receptor-binding domain of the follicular stimulating hormone (FSH) β-subunit. We show that the FSH antibody binds FSH specifically and blocks its action on osteoclast formation in vitro. When injected into ovariectomized mice, the FSH antibody attenuated bone loss significantly not only by inhibiting bone resorption, but also by stimulating bone formation.


    Zhu LL, Blair H, Cao J, Yuen T, Latif R, Guo L, Tourkova IL, et al