•  
     
     
    Type Size
     

    Alternative transcripts of Triggering receptor expressed on myeloid cells like transcript-1 inhibits the Triggering receptor expressed on myeloid cell-2

    Triggering receptor expressed on myeloid cells (TREM) like transcript-1 (TLT-1) is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-baring TREM family protein. In this study, we identified an alternative transcript of TLT-1, namely TLT-1s, which has very short extracellular immunoglobulin (Ig) domain (202 amino acids). TLT-1s was mainly expressed in macrophages and osteoclast precursor cells. Upon RANKL stimulation, TLT-1s mRNA and protein levels were gradually decreased in BMMs. Significantly, silencing of TLT-1s strongly enhanced the formation and resorption activity of osteoclast, while forced expression of TLT-1s reduced osteoclast formation.

    http://www.ncbi.nlm.nih.gov/pubmed/22761415

    Yoon SH, Lee YD, Ha J, Lee Y, Kim HH

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Review our Policies and Procedures for more details