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    Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice

    In this study, the authors examined the role of Gsα signaling in cells of the early osteoblast lineage in vivo by conditionally deleting Gsα from osterix-expressing cells. This led to severe osteoporosis with fractures at birth, a phenotype that was found to result from impaired bone formation rather than increased resorption. In addition, the number of committed osteoblast progenitors was diminished in both bone marrow stromal cells and calvarial cells of mutant mice. In the absence of Gsα, expression of sclerostin and dickkopf1 (Dkk1), inhibitors of canonical Wnt signaling, was markedly increased; which was accompanied by reduced Wnt signaling in the osteoblast lineage cells.


    Wu JY, Aarnisalo P, Bastepe M, Sinha P, Fulzele K, Selig MK