•  
     
     
    Type Size
     

    An Akt-dependent increase in canonical Wnt signalling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts

    J Biol Chem. 2011 May 12. [Epub ahead of print]

    Both this paper and the paper by Yang et al demonstrate the ability of strontium ranelate to increase canonical Wnt signaling and by this mechanism enhance bone formation. In addition, Rybchyn MS et al also finds that strontium inhibits sclerostin production.
    Authors: Rybchyn MS, Slater M, Conigrave AD, Mason RS

    J Biol Chem. 2011 May 12. [Epub ahead of print]

    Full Text