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    A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2

    Proc Natl Acad Sci U S A. 2011 May 31. [Epub ahead of print]

    In this study, the authors examined whether microRNAs (miRNAs) can control the osteogenic activity of Runx2 and affect osteoblast maturation. Using 3'UTR luciferase reporter, immunoblot, and mRNA stability assays, they demonstrated that a number of miRNAs were expressed during differentiation of osteoblasts and chondrocytes and these directly attenuated Runx2 protein accumulations in developing cells.  They conclude that osteoblastogenesis is influenced by an elaborate network of miRNAs, which directly target Runx2.

    Zhang Y, Xie RL, Croce CM, Stein JL, Lian JB, van Wijnen AJ, Stein GS