•  
     
     
    Type Size
     

    Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand

    Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):768-73. Epub 2010 Dec 27.

    These authors find that CD40 ligand, which regulates T-lymphocyte function, is necessary for estrogen withdrawal to promote bone loss in mice.

    Authors: Li JY, Tawfeek H, Bedi B, et. al

    The bone loss induced by ovariectomy (ovx) has been linked to increased production of osteoclastogenic cytokines by bone marrow cells, including T cells and stromal cells (SCs). It is presently unknown whether regulatory interactions between these lineages contribute to the effects of ovx in bone, however. Here, we show that the T-cell costimulatory molecule CD40 ligand (CD40L) is required for ovx to expand SCs; promote osteoblast proliferation and differentiation; regulate the SC production of the osteoclastogenic factors macrophage colony-stimulating factor, receptor activator of nuclear factor-κB ligand, and osteoprotegerin; and up-regulate osteoclast formation. CD40L is also required for ovx to activate T cells and stimulate their production of TNF. Accordingly, ovx fails to promote bone loss and increase bone resorption in mice depleted of T cells or lacking CD40L. Therefore, cross-talk between T cells and SCs mediated by CD40L plays a pivotal role in the disregulation of osteoblastogenesis and osteoclastogenesis induced by ovx.

    Full Text

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Review our Policies and Procedures for more details