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    IL-23 Is Critical for Induction of Arthritis, Osteoclast Formation, and Maintenance of Bone Mass.

    These authors found that systemic IL-23 exposure in mice induced chronic arthritis, severe bone loss, and myelopoiesis in the bone marrow and spleen, which resulted in increased osteoclast differentiation and systemic bone loss. Bone marrow macrophages derived from IL-23 deficient mice showed a slower in vitro maturation into osteoclasts and resorption capacity. This correlated with fewer multinucleated osteoclast-like cells and more trabecular bone volume and number in 26-wk-old male IL-23 deficient mice compared with controls. These data suggest that IL-23 regulates the abundance and differentiation of an osteoclast precursor cell.

    http://www.jimmunol.org/content/187/2/951.long

    Adamopoulos IE, Tessmer M, Chao CC, Adda S, Gorman D, Petro M, et al