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    Hypoxia inducible factor-1α is a negative regulator of load-induced bone formation.

    These authors demonstrate that hypoxia-inducible factor 1α (Hif-1α) is acutely upregulated in response to exogenous mechanical stimuli by mechanisms that rely on prostanoid signaling and Akt/mTOR activation.  In addition, mice lacking Hif-1α in osteoblasts and osteocytes form more bone when subjected to tibia loading because of increased osteoblast activity.  These data argue that Hif-1α is a negative regulator of the bone formation that is induced by mechanical loading.

    http://www.jbc.org/content/early/2011/11/12/jbc.M111.276683.long

    Riddle RC, Leslie JM, Gross TS, Clemens TL