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    Decreased PTH Levels Accompanied by Low Bone Formation Are Associated with Vertebral Fractures in Postmenopausal Women with Type 2 Diabetes

    This study investigated the association between vertebral fractures (VF) and bone turnover markers in patients with type 2 diabetes (T2DM).  Multivariate regression analysis showed that parathyroid hormone (PTH) levels of T2DM patients were significantly and positively correlated with osteocalcin (OC). When participants were divided into two subgroups based on mean PTH and OC levels, the group of T2DM women with lower PTH and lower OC levels had a significantly higher risk of VF than those with higher PTH and higher OC levels after adjusting for age, body mass index, hemoglobin A(1c), creatinine, 25-hydroxyvitamin D, and lumbar bone mineral density.


    Yamamoto M, Yamaguchi T, Nawata K, Yamauchi M, Sugimoto T.