•  
     
     
    Type Size
     

    Circulating αKlotho influences phosphate handling by controlling FGF23 production

    The goal of this study was to test whether circulating αKlotho (cKL), which is a cleavage product of membrane-bound Klotho, regulates phosphate handling by influencing FGF23 expression.  Mice, treated with an adeno-associated virus expressing cKL, exhibited dose-dependent hypophosphatemia and hypocalcemia, with markedly elevated FGF23. These animals also manifested fractures, reduced bone mineral content, expanded growth plates, and severe osteomalacia, with highly increased bone Fgf23 mRNA (>150 fold).

    Smith RC, O’Bryan LM, Farrow EG, Summers LJ, Clinkenbeard EL, Roberts JL, et al.

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Review our Policies and Procedures for more details