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    Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss

    PLoS One. 2010 Aug 20;5(8).

    The authors find that silencing of PTH receptor 1 (PPR) in T cells of mice blocks the bone loss and the osteoclastic expansion induced by parathyroid hormone treatment. They conclude that PPR signaling in T cells is central for PTH-induced reduction of bone mass.
    Authors: Tawfeek H, Bedi B, Li JY, et. al

    Hyperparathyroidism in humans and continuous parathyroid hormone (cPTH) treatment in mice cause bone loss by regulating the production of RANKL and OPG by stromal cells (SCs) and osteoblasts (OBs). Recently, it has been reported that T cells are required for cPTH to induce bone loss as the binding of the T cell costimulatory molecule CD40L to SC receptor CD40 augments SC sensitivity to cPTH. However it is unknown whether direct PTH stimulation of T cells is required for cPTH to induce bone loss, and whether T cells contribute to the bone catabolic activity of PTH with mechanisms other than induction of CD40 signaling in SCs.

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