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    Autophagy proteins regulate the secretory component of osteoclastic bone resorption.

    The authors show that proteins, which are essential for autophagy, including Atg5, Atg7, Atg4B, and LC3, are important for generating the osteoclast ruffled border, the secretory function of osteoclasts, and bone resorption in vitro and in vivo. Further, Rab7, which is required for osteoclast function, localized to the ruffled border in an Atg5-dependent manner. They conclude that autophagy proteins participate in polarized secretion of lysosomal contents into the extracellular space in osteoclasts by directing lysosomes to fuse with the plasma membrane.


    Deselm CJ, Miller BC, Zou W, Beatty WL, van Meel H, Takahata Y, et al