In this study the authors investigated the in vivo role of central estrogen receptor-α (ERα) expression on bone mass. Nestin-Cre mice were crossed with ERα(flox) mice to generate mice lacking ERα expression specifically in nervous tissue (nestin-ERα(-/-)). Bone mineral density was increased in both the trabecular and cortical bone compartments of nestin-ERα(-/-) mice compared with controls. The high bone mass phenotype in nestin-ERα(-/-) mice was mainly caused by increased bone formation. Serum leptin levels were elevated as a result of increased leptin expression in white adipose tissue (WAT) and slightly increased amount of WAT in nestin-ERα(-/-) mice. Leptin receptor mRNA levels were reduced in the hypothalamus but not in bone.
Ohlsson C, Engdahl C, Börjesson AE, Windahl SH, Studer E, Westberg L, et al