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    ACTH protects against glucocorticoid-induced osteonecrosis of bone

    Proc Natl Acad Sci U S A. 2010 Apr 26. [Epub ahead of print]


    In this paper the authors argue that ACTH has direct effects on bone, which prevent osteonecrosis that is mediated by glucocorticoid treatment. These actions of ACTH are mediated at least in part by stimulation of VEGF.
      

    Authors: Zaidi M, Sun L, Robinson LJ, et. al

    We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.

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