These authors demonstrate that administration of Interleukin 33 (IL-33), a new member of the IL-1 family, to mice inhibited cartilage destruction, systemic bone loss, and osteoclast differentiation in a mouse model of inflammatory arthritis. They conclude that IL-33 is an important bone-protecting cytokine and may be of therapeutic benefit in treating pathologic bone resorption.
Zaiss MM, Kurowska-Stolarska M, Böhm C, Gary R, Scholtysek C, Stolarski B et al
J Immunol. 2011 Apr 22. [Epub ahead of print]