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    Bone microstructural changes revealed by HRpQCT imaging and elevated DKK1 and MIP-1α levels in patients with monoclonal gammopathy of undetermined significance.

    To better define the skeletal effects of the syndrome of monoclonal gammopathy of unknown significance (MGUS), the authors performed BMD and high resolution peripheral quantitative CT (HRpQCT) measurements in 50 MGUS patients and 100 matched control subjects. MGUS patients had decreased BMD at the femoral neck and total femur but no differences at other sites. HRpQCT showed markedly diminished cortical thickness and a concomitant increase in endocortical area. Serum levels of the Wnt pathway inhibitor DKK1 and osteoclast activating factor MIP-1α were also significantly elevated in patients with MGUS.  These data suggest that cytokines may influence bone loss in MGUS.


    Ng AC, Khosla S, Charatcharoenwitthaya N, Kumar SK, Achenbach SJ, Holets MF, et al