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    Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

    In human rheumatoid arthritis (RA), the most severe inflammatory joint disease, autoantibodies against citrullinated proteins are among the strongest risk factors for bone destruction.  The authors found a strong association between autoantibodies against citrullinated proteins and serum markers for osteoclast-mediated bone resorption in RA patients.  In addition, human autoantibodies against mutated citrullinated vimentin bound osteoclast surfaces and produced a robust induction of osteoclastogenesis and bone-resorptive activity in vitro and in vivo. 


    Harre U, Georgess D, Bang H, Bozec A, Axmann R, Ossipova E, Jakobsson PJ, et al.