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    miR-218 Directs a Wnt Signaling Circuit to Promote Differentiation of Osteoblasts and Osteomimicry of Metastatic Cancer Cells.

    The authors show that micro RNA miR-218 is induced during osteoblast differentiation and has potent osteogenic properties. miR-218 promoted commitment and differentiation of bone marrow stromal cells by activating a positive Wnt signaling loop by downregulating Sclerostin (SOST), Dickkopf2 (DKK2) and secreted frizzled-related protein2 (SFRP2). In metastatic breast cancer cells but not in normal mammary epithelial cells, miR-218 enhances Wnt activity and abnormal expression of osteoblastic genes (osteomimicry) that contribute to the homing and growth of metastatic cells in bone.

    http://www.jbc.org/content/early/2012/10/11/jbc.M112.377515.long

    Hassan MQ, Maeda Y, Taipaleenmaki H, Zhang W, Jafferji M, Gordon JA, et al