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    A pooled analysis of vitamin D dose requirements for fracture prevention

    In this study the authors performed a meta-analysis of participant-level data from 11 double-blind, randomized, controlled trials of oral vitamin D supplementation compared to treatment with placebo or calcium alone in persons 65 years of age or older. Primary end points were the incidence of hip and nonvertebral fractures. When the authors examined subjects based on their actual intake of vitamin D, they found that the quartile treated with the highest dose (792 to 2000 IU/ day, median = 800 IU/day), had a significant (30%) reduction in the incidence of hip fractures (HR = 0.70, CI = 0.58-0.86) and a 14% reduction in the incidence of nonvertebral fractures (HR = 0.86, CI = 0.76–0.96) compared to the controls. 


    Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, et al