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    Serum 25-hydroxyvitamin D concentration and risk for major clinical disease events in a community-based population of older adults: a cohort study.

    The goal of this study was to evaluate the relationship of 25-hydroxyvitamin D concentration with the incidence of major clinical disease events that are pathophysiologically relevant to vitamin D. Participants were 1621 white older adults.  The authors found that the threshold concentrations of 25-(OH)D associated with increased risk for relevant clinical disease events center near 50 nmol/L (20 ng/mL).


    de Boer IH, Levin G, Robinson-Cohen C, Biggs ML, Hoofnagle AN, Siscovick DS, Kestenbaum B.