The authors examined the relationship of brown adipose tissue (BAT) and bone mass in a pediatric population. BAT was determined by fluorodeoxyglucose-positron emission tomography/computed tomography. There were significant correlations seen between BAT volume and the cross-sectional dimensions of the bone (r values between 0.68 and 0.77; all P ≤ 0 .001). Multiple regression analyses indicated that the volume of BAT predicted femoral cross-sectional area and cortical bone area, even after accounting for height, weight, and gender. However, the addition of muscle as an independent variable decreased the contribution of BAT, suggesting that muscle mass may mediate the effect of BAT on bone.
Ponrartana S, Aggabao PC, Hu HH, Aldrovandi GM, Wren TA, Gilsanz V.