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    Cdh1 Regulates Osteoblast Function through an APC/C-Independent Modulation of Smurf1

    In this manuscript the authors examine the role of Cdh1 an E3 ubiquitin ligase in osteoblast function.  They find that it promotes E3 ligase activity of Smurf1 by a mechanism that is independent of the E3 ligase activity of Cdh1.  These studies identify a cell-cycle-independent function of Cdh1 and establish it as an upstream regulator of Smurf1 activity. 


    Wan L, Zou W, Gao D, Inuzuka H, Fukushima H, Berg AH, et al