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    Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development.

    Leukemia/lymphoma-related factor (LRF) is induced during the development of bone-resorbing osteoclasts.  In this manuscript it is found that LRF negatively regulates osteoclast differentiation by repressing nuclear factor of activated T cells c1 (NFATc1) induction in the early phase of osteoclast development, while positively regulating osteoclast-specific genes by functioning as a coactivator of NFATc1 in the bone resorption phase. The stage-specific distinct functions of LRF were demonstrated in two lines of conditional knockout mice in which LRF was deleted in the early or late phase of osteoclast development.


    Tsuji-Takechi K, Negishi-Koga T, Sumiya E, Kukita A, Kato S, Maeda T et al