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    Runx1-mediated regulation of osteoclast differentiation and function.

    The authors demonstrate that Runx1 is a negative regulator of osteoclast differentiation. Mice lacking Runx1 in preosteoclasts (CD11b Cre;Runx1F/F) exhibited significant loss of femoral trabecular and cortical bone mass compared to the Cre negative mice. Additionally, serum levels of collagen type 1 cross-linked C-telopeptide, a biomarker of osteoclast-mediated bone resorption, were significantly elevated in CD11b-Cre;Runx1F/F mice compared to Runx1F/F mice and CD11b-Cre;Runx1F/F mice had increased osteoclasts on bone.

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