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    PPARβ/δ governs Wnt signaling and bone turnover.

    The authors find that PPARβ/δ is a key regulator of bone turnover and the crosstalk between osteoblasts and osteoclasts. Activation of PPARβ/δ amplified Wnt-dependent and β-catenin–dependent signaling and gene expression in osteoblasts, resulting in increased expression of osteoprotegerin (OPG) and attenuation of osteoblast-mediated osteoclastogenesis. PPARβ/δ-deficient mice had lower Wnt signaling activity, lower serum concentrations of OPG, higher numbers of osteoclasts and osteopenia.

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