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    Vitamin D-binding protein and vitamin D status of black Americans and white Americans

    In this article the authors measured serum levels of total 25-hydroxyvitamin D, vitamin D–binding protein (VDBP), and parathyroid hormone as well as bone mineral density (BMD) in black and white Americans. They also estimated levels of bioavailable 25-hydroxyvitamin D in participants.  They found that there were significant differences in the level of VDBP between black and white Americans, with black Americans having, on average, about half the level of whites while white Americans had significantly higher total 25-hydroxyvitamin D levels. However, bioavailable levels of vitamin D in both ethnic groups were essentially identical.  They conclude that; “low levels of total 25-hydroxyvitamin D probably do not indicate true vitamin D deficiency when levels of vitamin D–binding protein are also low, as in many black Americans. Bioavailable 25-hydroxyvitamin D may be a more appropriate cross-racial marker of vitamin D sufficiency; however, investigations in populations with overt vitamin D deficiency are required before routine clinical use is warranted”.

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