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    OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.

    In this study the authors demonstrate that the osteoclast-associated receptor (OSCAR), which is present on osteoclast precursor cells and amplifies the ability of RANKL to stimulate osteoclast formation, binds and is activated by specific motifs within fibrillar collagens.  Importantly, these collagen motifs are present on bone surfaces where osteoclasts undergo maturation and terminal differentiation in vivo.  Hence, these findings imply that OSCAR-collagen interactions are involved in the relatively unique ability of bone to facilitate osteoclastogenesis in vivo. 


    Barrow AD, Raynal N, Andersen TL, Slatter DA, Bihan D, Pugh N, et al