Type Size

    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

    The authors performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry.  They found 56 loci associated with BMD at genome-wide significance of which 32 were new. Several of these clustered within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, they also discovered loci that were localized to genes not known to have a role in bone biology.  In addition fourteen BMD-associated loci were also associated with fracture risk


    Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, et al.