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    Plasma Sphingosine 1-Phosphate Levels and the Risk of Vertebral Fracture in Postmenopausal Women

    The authors investigated if plasma Sphingosine 1-Phosphate (S1P) levels were a predictor for osteoporotic vertebral fracture (VF) risk. They found that S1P levels were markedly higher in subjects with VF (7.49 ± 3.44 μmol/liter) than in those without VF (5.58 ± 2.01 μmol/liter; P = 0.001) and increased in a dose-response manner as the number of VF increased (P for the trend <0.001), even after adjustment for lumbar spine BMD and potential confounders.


    Kim BJ, Koh JM, Lee SY, Lee YS, Lee SH, Lim KH, et al