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    Serum Sclerostin and Risk of Hip Fracture in Older Caucasian Women

    In this paper the authors demonstrate that women with the highest serum sclerostin levels had a risk of hip fracture that was significantly greater than women in the lowest quartile (HR = 3.41 95% CI = 1.66-6.99). Furthermore, when the group was divided in half according to bone mass, those with the lowest BMD and the highest serum sclerostin levels had over 20 times greater risk of hip fracture compared to women with the highest bone mass and the lowest serum sclerostin level (HR 22.3, 95% CI 5.8-86.3).


    Arasu A, Cawthon PM, Lui LY, Do TP, Arora PS, Cauley JA, et al