•  
     
     
    Type Size
     

    Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling.

    The authors compared the skeletal phenotypes of wild-type and TSH receptor (TSHR)-knockout mice that were rendered hyperthyroid. They found that hyperthyroid mice lacking TSHR had greater bone loss and resorption than hyperthyroid wild-type mice, thereby demonstrating that the absence of TSH signaling contributes to bone loss.

    http://www.jci.org/articles/view/63948

    Baliram R, Sun L, Cao J, Li J, Latif R, Huber AK, et al

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. Review our Policies and Procedures for more details