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    Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling.

    The authors compared the skeletal phenotypes of wild-type and TSH receptor (TSHR)-knockout mice that were rendered hyperthyroid. They found that hyperthyroid mice lacking TSHR had greater bone loss and resorption than hyperthyroid wild-type mice, thereby demonstrating that the absence of TSH signaling contributes to bone loss.


    Baliram R, Sun L, Cao J, Li J, Latif R, Huber AK, et al