Editorial: Changing of the Guard
Article: Vitamin D in Pregnancy and Lactation
Calcitriol, the active form of vitamin D, is necessary to maintain adequate calcium absorption during pregnancy, but not during lactation in mice, despite the heightened calcium absorption requirements in both conditions.
Article: Switching Gα11 in FHH2
Familial Hypocalciuric Hypercalcemia (FHH-2) is caused by heterozygous loss-of-function mutation of Gα11. However, allosteric modulation of the calcium sensing receptor (CaSR) by cinacalcet rectifies the effect of the downstream mutation by increasing signaling through the normal Gα11 allele.
Article: Cortical Bone Deficits in Diabetes
Bone mineral density is normal or even higher than normal in type-2 diabetes mellitus. Defects in cortical bone may account for the higher fracture risk in these patients, despite normal trabecular bone mass.
Article: PTHrP in Normal Bone Homeostasis
PTRrP is not involved in normal calcium homeostasis in adults. However, PTHrP is secreted by osteocytes (and possibly osteoblasts) in adult mice, and has paracrine and autocrine actions on bone forming cells, thus contributing to normal bone remodeling.
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