Web Editor Blog – Measuring Vitamin D in Serum: Have We Been Doing It All Wrong?
Date: December 03, 2013
In his latest Web Editor blog post, Dr. Joe Lorenzo discusses the problems researchers have historically faced when using vitamin D levels as predictors of osteoporosis and fragility fractures. Lorenzo writes that while it is expected that individuals with lower total circulating vitamin D levels would have weaker bones, that’s not always the case. The hypothesis holds up for those of a particular ancestry, he says, but “falls apart” when comparing individuals of different racial groups. “In the United States, comparison of the bone mass and the incidence of osteoporosis in white and black Americans demonstrates that on average, bone mass is lower and the incidence of osteoporosis is higher in white Americans compared to black Americans. Counterintuitively, white Americans have significantly higher mean total serum 25 OH vitamin D levels than do black Americans.” Lorenzo also presents new research from Powe et al that offers an explanation of the paradox. Read the full post to learn more.