There is no doubt that stem cells have captured the attention of both the scientific community and the public at large, and are touted to hold great promise for the fields of tissue engineering and regenerative medicine. Yet to date, there are very limited examples of success in using stem cells, including in the skeletal system. Dr. Robey will briefly review the history of skeletal stem cell/bone marrow stromal cell (SSC/BMSC) biology and their developmental origins. Dr. Robey will then describe the assays that have been developed that rigorously test for their functionality and their stemness (differentiation capacity and ability to self-renew). Lastly, Dr. Robey will describe how SSCs/BMSCs have been used in tissue engineering and regenerative medicine, the potential mechanisms of action, and hurdles that we face in bringing the promise of stem cell therapy to fruition.
- Understand how to evaluate stem cells that can be used for skeletal regeneration
- Distinguish between different forms of cell and stem cell therapies
- Appreciate the precise testing needed to determine efficacy of cell and stem cell therapies