Research into the biology of extracellular vesicles (EVs), including exosomes and microvesicles, has expanded significantly with advances in EV isolation techniques, a better understanding of the surface markers that characterize EVs, and greater information derived from -omics approaches on the proteins, lipids, mRNAs, and microRNAs (miRNAs) transported by EVs. EVs now appear to be involved in a number of degenerative conditions that impact the musculoskeletal system including aging, sarcopenia, and osteoporosis. This webinar will provide an overview of the cellular mechanisms of EV biogenesis, the role of EVs in bone intercellular communication and muscle-bone crosstalk, and future directions in EV research related to muscle and bone disorders.
- Describe various tools and approaches for EV isolation, characterization and analysis of EV biogenesis and cellular uptake.
- Define the role(s) of extracellular vesicles in bone cell communication, muscle-bone crosstalk and bone loss.
- Identify future research directions that can leverage knowledge of EV biology to improve treatment and prevention strategies for muscle and bone diseases.