• Apr 10, 2020 | Webinar

    ASBMR Webinar: Mechanosensitive Osteocytes: Insights into How the Osteocytes Control the Bone Response to Bone Loading and Unloading

    Jean Jiang, Ph.D., University of Texas Health Science Center at San Antonio, USA

    The skeleton adapts to mechanical usage and mechanical loading promotes bone formation and remodeling. Although most bone cells are involved in mechanosensing, it is well accepted that osteocytes are the principal mechanosensory cells. Osteocytes are embedded inside the bone mineral matrix and have stellate morphology with small cell body and long dendritic processes. The long dendritic processes of osteocytes form a network not only connecting the neighboring osteocytes, but also the cells on the bone surface, such as osteoblasts and osteoclasts. Recently, morphological studies also show the connection of osteocytes with bone marrow and blood vessels.  The osteocyte has been perceived as the center of bone remodeling by coordinating both osteoblast and osteoclast function, and also as the initiator of bone remodeling by sensing the bone matrix. Osteocyte cell body and processes are surrounded by fluid-filled space, forming an extensive lacuno-canalicular network. Various studies suggest that flow of interstitial fluid driven by extravascular pressure is a likely stress-related factor that transmits mechanical stimulation to bone cells. Dendritic processes of osteocytes are postulated as the mechanical sensory region on osteocytes. The mechanisms by which osteocytes sense and respond to mechanical loading and unloading in osteocytes are active research focuses in many laboratories.

    Educational Objectives

    1) Understand the current models of mechanical stimulation on osteocytes, mechanosensory areas of osteocytes and primary approaches in vivo and in vitro, and critical mechanosensory molecules involved

    2) Roles of osteocytic connexin and pannexin channels in mechanostransduction, and signaling mechanisms activated by mechano-stimulation.

    3) Relevance to physiology and pathology of the bone tissues, and challenges and future research directions.

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