Oct 11, 2012
The Osteocyte: What is it? Where did it come from? What does it do?
Molecular Cellular and Genetic Determinants of Bone Structure and Formation
Osteocytes are the most abundent cells in bone. Osteocytes are differentiated osteoblasts that live within the bone surrounded by matrix but are highly connected among themselves and with other bone/bone marrow cells. Osteocytes orchestrate the function of osteblasts and osteoclasts inresponse to both mechanical and hormonal cues. Osteocytes produce and secrete factors (such as sclerostin) that affect other bone cells by paracrine/autocrine mechanisms. Ostecytes produce and secrete hormones (such as FGF23) that affect other tissues by endocrine mechanisms.
Length: 70 minutes