ASBMR 2023 Symposium: Osteocytes in Bone Health and Disease and as Therapeutic Target Cells

The ASBMR 2023 Symposium was held on Thursday, October 12, 2023, one day prior the 2023 Annual Meeting, at the Vancouver Convention Centre in Vancouver, BC, Canada. Organized by Teresita Bellido, PhD, Natalie Sims, PhD and Marc Wein, MD, PhD, the goal of this topical meeting was to review the advances in basic, translational and clinical research on the role of osteocytes in the biology and pathophysiology of bone and how to target osteocytes with therapeutic goals.

Questions? Contact the ASBMR Business office by email at asbmr@asbmr.org or by phone at +1 (202) 367-1161. 

Program

Thursday, October 12, 2023
Vancouver Convention Centre, West Ballroom C

7:15 am - 8:00 am

Continental Breakfast

8:00 am – 8:15 am

Opening Keynote

Chair: Teresita Bellido, PhD, University of Arkansas for Medical Sciences (United States), Natalie Sims, PhD, St. Vincent's Institute of Medical Research (Australia) & Marc Wein, MD, PhD, Massachusetts General Hospital (United States)

8:15 am – 9:45 am

Session 1: Osteocytes and Mechanobiology

Co-Chairs: Joel Boerckel, PhD, University of Pennsylvania (United States) & Virginia Ferguson, PhD, University of Colorado (United States)

• Harnessing mechanosensitive pathways - Alex Robling, PhD, Indiana University (United States) 
• Mechanotransduction by the Piezo1 pathway in osteocytes – Jinhu Xiong, PhD, University of Arkansas for Medical Sciences (United States)
• Osteocyte Lacuno-canalicular architecture and bone adaptation to mechanical signals - Richard Weinkamer, PhD, Max Planck Institute of Colloids and Interfaces (Germany)

9:45 am – 10:00 am

Break

10:00 am – 11:15 am

Session 2: Osteocytes and Hormonal Actions: In and Out

Co-Chairs: Sang Wan Kim, MD, Seoul National University, (Republic of Korea) & Katherine Motyl, PhD, Maine Medical Center (United States)

• Osteocytes in PTH action: More than just calcium - Paola Divieti Pajevic, MD, PhD, Boston University (United States)
• Phosphate sensing and FGF23: The kidney/bone axis – Eugene Rhee, MD, Massachusetts General Hospital (United States)
• Estrogen and Semaphorin crosstalk in osteocytes and again – Hiroshi Takayanagi, MD, PhD, The University of Tokyo (Japan) 

11:15 am – 12:15 pm

Lunch and Poster Session

12:15 pm – 1:30 pm

Session 3: Osteocytes as part of the bone/bone marrow niche

Co-Chairs: Joy Wu, MD, PhD, Stanford University (United States) and Michelle McDonald, PhD, The Garvan Institute of Medical Research (Australia)

• Bidirectional notch signaling in osteocytes and myeloma cells - Jesus Delgado-Calle, PhD, University of Arkansas for Medical Sciences (United States) 
• Sclerostin and control of marrow fat – Michaela Reagan, PhD, Maine Medical Center Research Institute (United States)
• PPAR gamma and osteocyte bioenergetics – Beata Lecka-Czernik, PhD, University of Toledo (United States) 

1:30 pm – 1:45 pm

Break

1:45 pm – 3:00 pm

Session 4: New technologies in osteocyte biology

Co-Chairs: Charles O'Brien, MD, University of Arkansas for Medical Sciences (United States) & Shirley Wang, PhD, Massachusetts General Hospital (United States)

• The osteocyte transcriptome - Peter Croucher, PhD, The Garvan Institute of Medical Research (Australia)
• Osteocytes: Let's look at them! - Sarah Dallas, PhD, University of Missouri - Kansas City (United States)
• New osteocyte-targeting genetic approaches with CRISPR interference - Melda Onal, PhD, University of Arkansas for Medical Sciences (United States)

3:00 pm – 3:15 pm

Break

3:15 pm – 4:30 pm

Session 5: Effects of Bone Diseases and Medications on Osteocytes

Co-Chairs: Amy Sato, PhD, University of Arkansas for Medical Sciences (United States) & Martina Rauner, PhD, TU Dresden (Germany)

• Sclerostin inhibition: Lessons from women and mice - Serge Ferrari, MD, Geneva University Hospital (Switzerland)
• Osteocyte senescence in aging and diabetes - Sundeep Khosla, MD, Mayo Clinic (United States)
• Osteocytes and rickets: Vitamin D and FGF23 action - Eva Liu, MD, Brigham and Women's Hospital (United States)

4:30 pm - 5:10 pm

Oral Presentations

5:10 pm – 6:00 pm

Poster Session and Reception

Supported in part by AMGEN, Inc. and Ultragenyx Pharmaceutical Inc. (as of July 26, 2023)