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    Skeletal Actions of Fasting-Induced Adipose Factor (FIAF).

    Fasting-induced adipose factor (FIAF) is an adipokine that gives rise to 2 further peptides in vivo, the N-terminal coiled-coil domain (FIAFCCD) and C-terminal fibrinogen-like domain (FIAFFLD). The authors found that FIAFCCD is a potent inhibitor of osteoclastogenesis and function in mouse bone marrow and RAW264.7 cell cultures, and in a resorption assay using isolated primary mature osteoclasts. FIAFCCD also stimulated osteoblast mitogenesis by approximately 30%. In comparison, FIAFFLD was only active at decreasing osteoblast mitogenesis, and intact FIAF had no effect in any of assay. These results suggest a novel mechanism by which adipose tissue may regulate bone resorption and skeletal health.

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