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    Osteoclast precursors in murine bone marrow express CD27 and are impeded in osteoclast development by CD70 on activated immune cells.

    The authors report that the related TNF family member CD70 and its receptor CD27 can mediate cross-talk between immune cells and OC precursors. They identified CD27 on a rare population (0.3%) of B220−c-Kit+CD115+CD11b-low cells in the mouse bone marrow (BM) that are highly enriched for osteoclastogenic potential.  They also found that sustained CD27/CD70 interactions caused an accumulation of OC precursors and a reduction in OC activity.

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