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    Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches.

    This article demonstrates that the cells producing the critical cytokine Cxcl12, which supports hematopoietic stem cells and immune cell progenitors in mouse bone marrow “niches” varied and that there were distinct subgroups of Cxcl12 producing cells for different progenitor populations.  Deletion of Cxcl12 from osteoblasts depleted certain early lymphoid progenitors but not HSCs or myeloerythroid progenitors, and did not mobilize these cells into circulation.  

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