In this study post-menopausal women with and without a history of low trauma ankle fracture had trabecular (Tb) and cortical volumetric bone mineral density, and Tb microarchitecture measured by high-resolution peripheral computed tomography of the tibia and radius. Finite element analysis was performed to estimate bone stiffness. It was found that fracture subjects had lower central trabecular bone density, lower Tb number, and increased separation compared to controls. In addition, whole-bone stiffness was 13-17% lower at the radius and tibia in fracture subjects. The authors conclude that low trauma ankle fractures should be considered similarly to other classical osteoporotic fractures.
Stein EM, Liu XS, Nickolas TL, Cohen A, Thomas V, McMahon DJ et al
J Clin Endocrinol Metab. 2011 Apr 20. [Epub ahead of print]